Category Archives: Sirtuins

Resveratrol Controversy Clarified

By admin | Published: March 7, 2013
Longstanding questions about how the red-wine ingredient resveratrol works at the molecular level have been answered by Harvard’s David Sinclair and colleagues in a paper that just appeared in Science. The new research supports the idea that the compound directly activates an enzyme called SIRT1 to induce effects in cells that are similar to those [...]
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Yes, Red Wine May Hold Some Answers. Recheck Dosage.

By admin | Published: December 16, 2011
If you’ve tuned into the resveratrol story over the past five years, you’ve probably heard that you’d need to take giant doses of the red-wine ingredient to do any good. That idea was based on mouse studies in 2006 that showed massive doses of the compound blocked bad effects of eating too much fat. A [...]
Also posted in aging, Diet and aging, Drugs and aging, Genetics of aging, Life Span, Obesity and aging, Resveratrol | Tagged , , , , , , | Comments closed

Sirtuin News For Mammals

By admin | Published: December 12, 2011
The negative buzz about sirtuins recently grew louder when Science ran a lengthy news piece on Dec. 2 titled, “Aging Genes: The Sirtuin Story Unravels.” The article played up studies in lower organisms casting doubt on earlier high-profile reports that sirtuin enzmes play major roles in aging, which in turn challenged the idea that they [...]
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Yet another twist on sirtuins—with leaping ant queens

By admin | Published: August 27, 2010
It’s not often that 33 scientists jointly pen a public complaint that an article in Science got things wrong. But in this week’s issue of Science nearly three dozen researchers working on sirtuins, the enzymes thought by many scientists to help induce the health- and longevity-promoting effects of calorie restriction (CR), complain in a letter [...]
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Two new twists on resveratrol

By admin | Published: August 13, 2010
A couple of significant developments in the resveratrol story occurred this week, but so far the media has focused only on the less important one of the two. I’ll get to the truly important news in a moment. First, here’s the story that hit the wires yesterday: The Healthy Lifespan Institute, a nonprofit cofounded by [...]
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On resveratrol and the beautiful mindset of Michael Faraday — Part 2

By admin | Published: July 20, 2010
If I’m conversant with apparently sound research that conflicts with the Sinclair/Sirtris take on resveratrol and sirtuins, you might ask, why haven’t I joined the skeptics who dismiss that take as a house of cards? It’s simple: There are a lot more studies—including a number of compelling in vivo experiments by researchers with no ties [...]
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On resveratrol and the beautiful mindset of Michael Faraday — Part 1

By admin | Published: July 20, 2010
In recent months, life-science blogs and journals have pulsated with negative vibes about resveratrol, the red-wine ingredient reported to show anti-aging effects in various animal species. The bad vibes have also been directed at sirtuins, the enzymes thought to mediate resveratrol’s benefits and at David Sinclair, the Harvard scientist who first reported that resveratrol can [...]
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